Abstract
Substituted N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides were investigated as inhibitors of genotype 1 HCV polymerase. Structure-activity relationship patterns for this class of compounds are discussed.
MeSH terms
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Benzothiadiazines* / chemical synthesis
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Benzothiadiazines* / chemistry
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Benzothiadiazines* / pharmacology
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Drug Evaluation, Preclinical
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Enzyme Inhibitors* / chemical synthesis
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Enzyme Inhibitors* / chemistry
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Enzyme Inhibitors* / pharmacology
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Molecular Structure
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Structure-Activity Relationship
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Sulfonamides* / chemical synthesis
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Sulfonamides* / chemistry
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Sulfonamides* / pharmacology
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Viral Nonstructural Proteins / antagonists & inhibitors*
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Viral Nonstructural Proteins / chemistry
Substances
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Benzothiadiazines
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Enzyme Inhibitors
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Sulfonamides
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Viral Nonstructural Proteins
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NS-5 protein, hepatitis C virus